Nothing new under the sun: Little new among psych meds in decades, Part II: The antipsychotics

“The data are in, and it is clear that . . .a[n] experiment has failed: despite decades of research and billions of dollars invested, not a single mechanistically novel drug has reached the psychiatric market in more than 30 years.”… Continue Reading


Atypical Attitudes: How The Atypicals Took the Fall in Dementia Patients–The Other Meds Catch Up

In 2008, the FDA put out the following: “For Immediate Release: FDA Requests Boxed Warnings on Older Class of Antipsychotic Drugs.” It said: The U.S. Food and Drug Administration today exercised its new authority . . .to require manufacturers of… Continue Reading


Atypical Attitudes: How The Atypicals Took the Fall in Dementia Patients–The Beginning of Trouble

It was indisputably bad news for the makers of the new, second-generation (or atypical) antipsychotics–a literal black mark on their name. It was April, 2005, and the FDA issued an advisory that would strike fear into the hearts of any elderly… Continue Reading


Diabetes Drug Or Dieter’s Dream? Metformin and Antipsychotic-Induced Weight Gain

With the roll-out of Clozaril, in 1989, with its promise to treat recalcitrant schizophrenics, the era of the second-generation, or ‘atypical,’ antipsychotics, was born. And there is much the atypicals offer over the first-generation antipsychotics, including freedom from fear from the… Continue Reading


Play It Again, Sam: Trying–and Failing–To Reproduce Scientific Results

With the release of Zyprexa, a second-generation antipsychotic, Eli Lilly was certain it had hit pay dirt. The second-generation antipsychotics, known as the atypical antipsychotics, or atypicals, had an improved side effect profile over the older antipsychotics, and the original… Continue Reading


The Bipolar Road Less Traveled: Beyond Lithium, Part I

Once upon a time, if you were diagnosed with bipolar disorder, you were treated with lithium. And, once upon a time, it worked. According to the Report of the Surgeon General, “Success rates of 80 to 90 percent were once… Continue Reading